Bone Abstracts

Although the heavy metal pollutant cadmium (Cd) is a well known teratogen, the mechanism behind Cd mediated teratogenicity is still unclear and it mainly targets the bone development. Previously we and other groups reported on the protective role of nitric oxide (NO), a key signaling molecule in the embryonic developmental process, against thalidomide and other teratogenic assaults also NO is considered to be a vital signaling molecule in the regulation of bone formation. The ...

Angiogenesis and osteogenesis are tightly linked and dependent on each other. Lipocalin 2 (LCN2) is a mechanoresponding adipokine, strongly upregulated in osteogenic cells subjected to microgravity (0.08–0.008 g), in which it impairs osteogenesis and upregulates the osteoclastogenic cytokine, RANKL. We investigated the role of LCN2 in the crosstalk between angiogenesis and osteogenesis in simulated microgravity conditions as a model of mechanical unloading. Mouse and huma...